Laboratoř imunobiologie

Publikace

  • 2024

  • Brabec T, Schwarzer M, Kováčová K, Dobešová M, Schierová D, Březina J, Pacáková I, Šrůtková D, Ben-Nun O, Goldfarb Y, Šplíchalová I, Kolář M, Abramson J, Filipp D, Dobeš J: Segmented filamentous bacteria-induced epithelial MHCII regulates cognate CD4+ IELs and epithelial turnover. J Exp Med 2024 221(1). [pubmed] [doi]
  • Filipp D, Manning J, Petrusová J: Extrathymic AIRE-Expressing Cells: A Historical Perspective. Adv Exp Med Biol 2024 1444: 33-49. [pubmed] [doi]
  • 2023

  • Brabec T, Vobořil M, Schierová D, Valter E, Šplíchalová I, Dobeš J, Březina J, Dobešová M, Aidarova A, Jakubec M, Manning J, Blumberg R, Waisman A, Kolář M, Kubovčiak J, Šrůtková D, Hudcovic T, Schwarzer M, Froňková E, Pinkasová T, Jabandžiev P, Filipp D: IL-17-driven induction of Paneth cell antimicrobial functions protects the host from microbiota dysbiosis and inflammation in the ileum. Mucosal Immunol 2023 16(4): 373-385. [pubmed] [doi]
  • Březina J., Filipp D.: Jak se ladí imunitní tolerance Vesmír 2023 Leden 2023(102): 38-42.
  • Petrusová J, Manning J, Filipp D: Envisioning a role for nuclear actin in prophase I spermatocytes. Front Cell Dev Biol 2023 11: 1295452. [pubmed] [doi]
  • Schwarzer M, Gautam UK, Makki K, Lambert A, Brabec T, Joly A, Šrůtková D, Poinsot P, Novotná T, Geoffroy S, Courtin P, Hermanová PP, Matos RC, Landry JJM, Gérard C, Bulteau AL, Hudcovic T, Kozáková H, Filipp D, Chapot-Chartier MP, Šinkora M, Peretti N, Boneca IG, Chamaillard M, Vidal H, De Vadder F, Leulier F: Microbe-mediated intestinal NOD2 stimulation improves linear growth of undernourished infant mice. Science 2023 379(6634): 826-833. [pubmed] [doi]
  • 2022

  • Březina J, Vobořil M, Filipp D: Mechanisms of Direct and Indirect Presentation of Self-Antigens in the Thymus. Front Immunol 2022 13: 926625. [pubmed] [doi]
  • Dibus N, Zobalova E, Monleon MAM, Korinek V, Filipp D, Petrusova J, Sedlacek R, Kasparek P, Cermak L: FBXO38 Ubiquitin Ligase Controls Sertoli Cell Maturation. Front Cell Dev Biol 2022 10: 914053. [pubmed] [doi]
  • Dobeš J, Ben-Nun O, Binyamin A, Stoler-Barak L, Oftedal BE, Goldfarb Y, Kadouri N, Gruper Y, Givony T, Zalayat I, Kováčová K, Böhmová H, Valter E, Shulman Z, Filipp D, Husebye ES, Abramson J: Extrathymic expression of Aire controls the induction of effective T17 cell-mediated immune response to Candida albicans. Nat Immunol 2022 23(7): 1098-1108. [pubmed] [doi]
  • Petrusová J, Manning J, Filipp D: AIRE in Male Fertility: A New Hypothesis. Cells 2022 11(19). [pubmed] [doi]
  • Petrusová J, Havalda R, Flachs P, Venit T, Darášová A, Hůlková L, Sztacho M, Hozák P: Focal Adhesion Protein Vinculin Is Required for Proper Meiotic Progression during Mouse Spermatogenesis. Cells 2022 11(13). [pubmed] [doi]
  • Petrusová J, Manning J, Kubovčiak J, Kolář M, Filipp D: Two complementary approaches for efficient isolation of Sertoli cells for transcriptomic analysis. Front Cell Dev Biol 2022 10: 972017. [pubmed] [doi]
  • Vobořil M, Březina J, Brabec T, Dobeš J, Ballek O, Dobešová M, Manning J, Blumberg RS, Filipp D: A model of preferential pairing between epithelial and dendritic cells in thymic antigen transfer. Elife 2022 11. [pubmed] [doi]
  • 2021

  • Pavkova I, Klimentova J, Bavlovic J, Horcickova L, Kubelkova K, Vlcak E, Raabova H, Filimonenko V, Ballek O, Stulik J: Outer Membrane Vesicles Participate in the Early Phase of Interaction With Macrophages. Front Microbiol 2021 12: 748706. [pubmed] [doi]
  • Splichalova I, Balounová J, Vobořil M, Brabec T, Sedlacek R, Filipp D: Deletion of TLR2 erythro-myeloid progenitors leads to embryonic lethality in mice. Eur J Immunol 2021. [pubmed] [doi]
  • Vacaresse N., Ferzoco A., Fillip D., Amemiya Y., Seth A., Andrews D., Kinoshita T., Julius M.: The Glycosylphosphatidylinositol Anchor Regulates T Cell Antigen Receptor Induced IL-2 Production Open Journal of Immunology 2021 11: 1-24.
  • Wang S, Ren D, Arkoun B, Kaushik AL, Matherat G, Lécluse Y, Filipp D, Vainchenker W, Raslova H, Plo I, Godin I: Lyl-1 regulates primitive macrophages and microglia development. Commun Biol 2021 4(1): 1382. [pubmed] [doi]
  • 2020

  • Borna S, Drobek A, Kralova J, Glatzova D, Splichalova I, Fabisik M, Pokorna J, Skopcova T, Angelisova P, Kanderova V, Starkova J, Stanek P, Matveichuk OV, Pavliuchenko N, Kwiatkowska K, Protty MB, Tomlinson MG, Alberich-Jorda M, Korinek V, Brdicka T: Transmembrane adaptor protein WBP1L regulates CXCR4 signalling and murine haematopoiesis. J Cell Mol Med 2020 24(2): 1980-1992. [pubmed] [doi]
  • Splichal I, Rychlik I, Splichalova I, Karasova D, Splichalova A: Toll-Like Receptor 4 Signaling in the Ileum and Colon of Gnotobiotic Piglets Infected with Typhimurium or Its Isogenic ∆ Mutants. Toxins (Basel) 2020 12(9). [pubmed] [doi]
  • Vobořil M, Brabec T, Dobeš J, Šplíchalová I, Březina J, Čepková A, Dobešová M, Aidarova A, Kubovčiak J, Tsyklauri O, Štěpánek O, Beneš V, Sedláček R, Klein L, Kolář M, Filipp D: Toll-like receptor signaling in thymic epithelium controls monocyte-derived dendritic cell recruitment and Treg generation. Nat Commun 2020 11(1): 2361. [pubmed] [doi]
  • 2019

  • Angelisová P, Ballek O, Sýkora J, Benada O, Čajka T, Pokorná J, Pinkas D, Hořejší V: The use of styrene-maleic acid copolymer (SMA) for studies on T cell membrane rafts. Biochim Biophys Acta Biomembr 2019 1861(1): 130-141. [pubmed] [doi]
  • Balounová J, Šplíchalová I, Dobešová M, Kolář M, Fišer K, Procházka J, Sedlacek R, Jurisicova A, Sung HK, Kořínek V, Alberich-Jorda M, Godin I, Filipp D: Toll-like receptor 2 expression on c-kit cells tracks the emergence of embryonic definitive hematopoietic progenitors. Nat Commun 2019 10(1): 5176. [pubmed] [doi]
  • Filipp D, Brabec T, Vobořil M, Dobeš J: Enteric α-defensins on the verge of intestinal immune tolerance and inflammation. Semin Cell Dev Biol 2019 88: 138-146. [pubmed] [doi]
  • Splichal I, Donovan SM, Jenistova V, Splichalova I, Salmonova H, Vlkova E, Neuzil Bunesova V, Sinkora M, Killer J, Skrivanova E, Splichalova A: High Mobility Group Box 1 and TLR4 Signaling Pathway in Gnotobiotic Piglets Colonized/Infected with , , Nissle 1917 and . Typhimurium. Int J Mol Sci 2019 20(24). [pubmed] [doi]
  • Yamano T, Dobeš J, Vobořil M, Steinert M, Brabec T, Ziętara N, Dobešová M, Ohnmacht C, Laan M, Peterson P, Benes V, Sedláček R, Hanayama R, Kolář M, Klein L, Filipp D: Aire-expressing ILC3-like cells in the lymph node display potent APC features. J Exp Med 2019 216(5): 1027-1037. [pubmed] [doi]
  • 2018

  • Dobeš J, Edenhofer F, Vobořil M, Brabec T, Dobešová M, Čepková A, Klein L, Rajewsky K, Filipp D: A novel conditional Aire allele enables cell-specific ablation of the immune tolerance regulator Aire. Eur J Immunol 2018 48(3): 546-548. [pubmed] [doi]
  • 2017

  • Kriz V, Krausova M, Buresova P, Dobes J, Hrckulak D, Babosova O, Svec J, Korinek V: Establishment of a tagged variant of Lgr4 receptor suitable for functional and expression studies in the mouse. Transgenic Res 2017 26(5): 689-701. [pubmed] [doi]
  • Stechova K, Sklenarova-Labikova J, Kratzerova T, Pithova P, Filipp D: Not Only Glycaemic But Also Other Metabolic Factors Affect T Regulatory Cell Counts and Proinflammatory Cytokine Levels in Women with Type 1 Diabetes. J Diabetes Res 2017 2017: 5463273. [pubmed] [doi]
  • 2016

  • Ballek O, Valečka J, Dobešová M, Broučková A, Manning J, Řehulka P, Stulík J, Filipp D: TCR Triggering Induces the Formation of Lck-RACK1-Actinin-1 Multiprotein Network Affecting Lck Redistribution. Front Immunol 2016 7: 449. [pubmed] [doi]
  • Chlubnová I, Králová B, Dvořáková H, Spiwok V, Filipp D, Nugier-Chauvin C, Daniellou R, Ferrières V: Biocatalyzed synthesis of difuranosides and their ability to trigger production of TNF-α. Bioorg Med Chem Lett 2016 26(6): 1550-3. [pubmed] [doi]
  • Vavrova K, Vrabcova P, Filipp D, Bartunkova J, Horvath R: Generation of T cell effectors using tumor cell-loaded dendritic cells for adoptive T cell therapy. Med Oncol 2016 33(12): 136. [pubmed] [doi]
  • 2015

  • Ballek O, Valečka J, Manning J, Filipp D: The pool of preactivated Lck in the initiation of T-cell signaling: a critical re-evaluation of the Lck standby model. Immunol Cell Biol 2015. [pubmed] [doi]
  • Balounová J, Šplíchalová I, Dobešová M, Alberich-Jorda M, Filipp D: EARLY ACTIVATION OF TLR2 LOCUS TRACKS THE EMERGENCE OF EMBRYONIC MULTIPOTENT HEMATOPOIETIC PROGENITORS WHICH CONTRIBUTE TO DEFINITIVE HEMATOPOIESIS Experimental Hematology 2015 43(9): S52-S52.
  • Dobeš J, Neuwirth A, Dobešová M, Vobořil M, Balounová J, Ballek O, Lebl J, Meloni A, Krohn K, Kluger N, Ranki A, Filipp D: Gastrointestinal Autoimmunity Associated With Loss of Central Tolerance to Enteric α-Defensins. Gastroenterology 2015 149(1): 139-50. [pubmed] [doi]
  • Janeckova L, Pospichalova V, Fafilek B, Vojtechova M, Tureckova J, Dobes J, Dubuissez M, Leprince D, Baloghova N, Horazna M, Hlavata A, Stancikova J, Sloncova E, Galuskova K, Strnad H, Korinek V: HIC1 Tumor Suppressor Loss Potentiates TLR2/NF-κB Signaling and Promotes Tissue Damage-Associated Tumorigenesis. Mol Cancer Res 2015 13(7): 1139-48. [pubmed] [doi]
  • Stancikova J, Krausova M, Kolar M, Fafilek B, Svec J, Sedlacek R, Neroldova M, Dobes J, Horazna M, Janeckova L, Vojtechova M, Oliverius M, Jirsa M, Korinek V: NKD1 marks intestinal and liver tumors linked to aberrant Wnt signaling. Cell Signal 2015 27(2): 245-56. [pubmed] [doi]
  • 2014

  • Balounová J, Vavrochová T, Benešová M, Ballek O, Kolář M, Filipp D: Toll-like receptors expressed on embryonic macrophages couple inflammatory signals to iron metabolism during early ontogenesis. Eur J Immunol 2014 44(5): 1491-502. [pubmed] [doi]
  • Härtlová A, Link M, Balounová J, Benešová M, Resch U, Strasková A, Sobol M, Philimonenko A, Hozák P, Krocová Z, Gekara N, Filipp D, Stulík J: Quantitative Proteomics Analysis of Macrophage-derived Lipid Rafts Reveals Induction of Autophagy Pathway at the Early Time of Francisella tularensis LVS infection. J Proteome Res 2014 13(2): 796-804. [pubmed] [doi]
  • Chlubnová I, Králová B, Dvořáková H, Hošek P, Spiwok V, Filipp D, Nugier-Chauvin C, Daniellou R, Ferrières V: The versatile enzyme Araf51 allowed efficient synthesis of rare pathogen-related β-D-galactofuranosyl-pyranoside disaccharides. Org Biomol Chem 2014 12(19): 3080-9. [pubmed] [doi]
  • 2013

  • Filipp D, Dobeš J: Imunita a tolerancia: Jin a Jang imunitného systemu Vesmír 2013 92: 224-227.
  • Stechová K, Kolář M, Filipp D: Lessons from the gene expression studies of immunocompetent cells in relationship to type 1 diabetes development. Gene Expression: New Research. 2013.
  • Vcelakova J, Blatny R, Halbhuber Z, Kolar M, Neuwirth A, Petruzelkova L, Ulmannova T, Kolouskova S, Sumnik Z, Pithova P, Krivjanska M, Filipp D, Stechova K: The Effect of Diabetes-Associated Autoantigens on Cell Processes in Human PBMCs and Their Relevance to Autoimmune Diabetes Development. J Diabetes Res 2013 2013: 589451. [pubmed] [doi]
  • 2012

  • Ballek O, Broučková A, Manning J, Filipp D: A specific type of membrane microdomains is involved in the maintenance and translocation of kinase active Lck to lipid rafts. Immunol Lett 2012 142(1-2): 64-74. [pubmed] [doi]
  • Filipp D, Ballek O, Manning J: Lck, Membrane Microdomains, and TCR Triggering Machinery: Defining the New Rules of Engagement. Front Immunol 2012 3(155): 1-14. [pubmed] [doi]
  • Neuwirth A, Dobeš J, Oujezdská J, Ballek O, Benešová M, Sumník Z, Včeláková J, Koloušková S, Obermannová B, Kolář M, Stechová K, Filipp D: Eosinophils from patients with type 1 diabetes mellitus express high level of myeloid alpha-defensins and myeloperoxidase. Cell Immunol 2012 273(2): 158-63. [pubmed] [doi]
  • Stechova K, Halbhuber Z, Hubackova M, Kayserova J, Petruzelkova L, Vcelakova J, Kolouskova S, Ulmannova T, Faresjö M, Neuwirth A, Spisek R, Sediva A, Filipp D, Sumnik Z: Case report: type 1 diabetes in monozygotic quadruplets. Eur J Hum Genet 2012 20(4): 457-62. [pubmed] [doi]
  • Stechova K, Kolar M, Blatny R, Halbhuber Z, Vcelakova J, Hubackova M, Petruzelkova L, Sumnik Z, Obermannova B, Pithova P, Stavikova V, Krivjanska M, Neuwirth A, Kolouskova S, Filipp D: Healthy first degree relatives of patients with type 1 diabetes exhibit significant differences in basal gene expression pattern of immunocompetent cells compared to controls: expression pattern as predeterminant of autoimmune diabetes. Scand J Immunol 2012 75(2): 210-219. [pubmed] [doi]
  • 2011

  • Merjava S, Neuwirth A, Tanzerova M, Jirsova K: The spectrum of cytokeratins expressed in the adult human cornea, limbus and perilimbal conjunctiva. Histol Histopathol 2011 26(3): 323-31. [pubmed]
  • 2010

  • Chlubnová I, Filipp D, Spiwok V, Dvoráková H, Daniellou R, Nugier-Chauvin C, Králová B, Ferrières V: Enzymatic synthesis of oligo-D-galactofuranosides and l-arabinofuranosides: from molecular dynamics to immunological assays. Org Biomol Chem 2010 8(9): 2092-102. [pubmed] [doi]
  • Jirsova K, Neuwirth A, Kalasova S, Vesela V, Merjava S: Mesothelial proteins are expressed in the human cornea. Exp Eye Res 2010 91(5): 623-9. [pubmed] [doi]
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