Institute of Molecular Genetics of the Czech Academy of Sciences
+ leukocyte signal transduction, + inflammation, + immune response, + autoinflammatory diseases, + membrane adaptor proteins
By studying autoinflammatory diseases that are characterized by spontaneous sterile inflammation of various tissues, we have found deregulated production of reactive oxygen species by neutrophil NADPH oxidase. Our findings suggest that this is a critical mechanism of inflammatory bone damage in the mouse model of autoinflammatory diseases. [pubmed] [doi]
We have discovered a so far uncharacterized membrane adaptor WBP1L that negatively regulates signalling through the chemokine receptor CXCR4. This receptor has a key role in haematopoiesis and cancer metastases. We have also described the function of the WBP1L adaptor in hematopoietic progenitors and leukemic cells. [pubmed] [doi]
We have discovered a new layer of regulation in antigen receptor signal transduction that determines the threshold for downstream pathway activation by Src-family kinases. These are key signal transducers of antigen receptor signalling in B and T cells. [pubmed] [doi]
