Laboratory of Cancer Biology

Research

Proteasome, cancer, protein degradation, cell cycle, survival

The main function of the ubiquitin-proteasome system (UPS) is to degrade unneeded or damaged proteins. Cullin-RING ubiquitin ligases (CRLs) mediate ubiquitination of numerous substrates. Our main research focus is to reveal novel substrates of CRLs involved in cancer progression, stress response or cell cycle. We presumed that these novel interactions could serve as potential therapeutic targets in cancer and other pathologies.

Figure 1. Isolation of different ubiquitin ligases (anti-FLAG) — **Left:** Isolation of different ubiquitin ligases (anti-FLAG).
**Right:** Subcellular localization of “orphan” ubiquitin ligase (red), DNA (blue), actin cytoskeleton (green).

Figure 2. Subcellular localization of “orphan” ubiquitin ligase (red), DNA (blue), actin cytoskeleton (green) — **Left:** Isolation of different ubiquitin ligases (anti-FLAG).
**Right:** Subcellular localization of “orphan” ubiquitin ligase (red), DNA (blue), actin cytoskeleton (green).

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