Institute of Molecular Genetics of the Czech Academy of Sciences
| Grant name | Provider | Duration | Investigator | Web |
|---|---|---|---|---|
| Identification and characterization of proteins involved in G-quadruplex and R-loop metabolism and their relationship with DNA replication | Czech Science Foundation | 2021-2025 | J. Dobrovolná | Go to website |
| Molecular mechanisms involved in reactivation of replication forks stalled by co-transcriptional R-loops | Czech Science Foundation | 2022-2024 | P. Janščák | Go to website |
| Functional classification of the TP53 gene variants with distinct penetrance and its use for better management of cancer prevention in mutation carriers | Ministry of Health | 2022-2025 | L. Macůrek | Go to website |
| Role of protein phosphatases in telomere maintenance and ribosomal biogenesis | Czech Science Foundation | 2024-2026 | L. Macůrek | Go to website |
| Grant name | Provider | Duration | Investigator | Web |
|---|---|---|---|---|
| Role of Wip1 phosphatase in the DNA damage response | Czech Science Foundation | 2010-2012 | L. Macůrek | Go to website |
| Structure and function of proteins involved in DNA damage signaling | Czech Science Foundation | 2012-2015 | L. Macůrek | Go to website |
| Dynamics of DNA damage response in cells | Czech Science Foundation | 2013-2016 | L. Macůrek | Go to website |
| Phosphorylation-mediated signalling in DNA damage response and cancer | Ministry of Education, Youth and Sports | 2014-2017 | L. Macůrek | Go to website |
| Role of R2TP complex in DNA damage response and cell proliferation | Czech Science Foundation | 2014-2016 | Z. Líčeníková Hořejší | Go to website |
| Role of PPM1D/Wip1 truncating mutations in cancer predisposition | Worldwide Cancer Research | 2014-2016 | L. Macůrek | Go to website |
| Bioinformatics and functional analyses of susceptibility variants supporting the NGS-based testing of hereditary cancers in the Czech Republic | Ministry of Health | 2016-2019 | L. Macůrek | Go to website |
| Role of deficient checkpoint barrier in cancerogenesis | Czech Science Foundation | 2016-2018 | L. Macůrek | Go to website |
| Analysis of stromal microenvironment, molecular and immunohistochemical aspects of malignant melanoma | Ministry of Health | 2016-2019 | L. Macůrek | Go to website |
| Novel mechanisms regulating the cell cycle progression and checkpoint | Czech Science Foundation | 2017-2019 | L. Macůrek | Go to website |
| Classification of variants of uncertain significance in CHEK2 and phenotypical characterization of tumours in carriers of deleterious variants | Ministry of Health | 2019-2022 | L. Macůrek | Go to website |
| Novel role of PPM1D/Wip1 phosphatase in chromatin organization | Czech Science Foundation | 2019-2021 | L. Macůrek | Go to website |
| Investigation of the control of bioenergetic plasticity of tumor by oncogenic switches | Czech Science Foundation | 2019-2021 | M. Elgendy | Go to website |
| Bioinformatics and functional analyses of susceptibility variants supporting the ngs-based testing of hereditary cancers in the Czech Republic - II | Ministry of Health | 2020-2023 | L. Macůrek | Go to website |
| Role of truncated PPM1D in genome instability and cancer development | Czech Science Foundation | 2020-2022 | L. Macůrek | Go to website |
| Impact of mutations in CHEK2 and other predisposing genes on development of breast and ovary carcinoma | Czech Academy of Sciences | 2022-2023 | L. Stolařová |
