Institute of Molecular Genetics of the Czech Academy of Sciences
The main aim of the two-week course is to inform the participants about the recent progress in the fields of molecular biology, genetics and biomedicine together with selected new biotechnology approaches.
Typical attendees are the first and second year PhD students from biomedical programs, but other participants are also very welcome. The course is accredited (MPGS0034) at the Charles University.
All lectures will be held in English by active scientists.
The course is composed of 43 lectures organized into the following thematic blocks:
DNA/cell nucleus: nuclear microstructure-function relationship, nuclear lamina, organization and function of the 3D genome, human genome structure and evolution, germline restricted chromosomes in birds.
RNA: organization and regulation of RNA polymerase II transcription, noncanonical RNA caps, transcription and splicing regulation, non-coding RNAs, small RNA pathways.
Proteins: eukaryotic protein synthesis, ribosome structure, structural biology tools, proteomics and proteomes, prions.
Cell biology and signaling: microtubules and signal transduction, microtubules in neuronal development, cytoskeleton and plant organelles, centrosomes and cilia, integrative biology of intermediate microfilaments.
Developmental biology: oocyte-to-zygote transition, planarian regeneration, induced pluripotent stem cells and organoids, zebrafish as a model system in developmental biology, comparative developmental biology of facial shape.
Biomedicine – genomics: rare genetic variants in Mendelian complex diseases, high-throughput sequencing methods, epigenetic disorders and therapy, antiviral prospects of gene editing, base and prime editors.
Biomedicine – cancer biology: germline mutations in cancer, ADP-ribose metabolism and DNA breaks in human disease, fibroblasts in mammary gland development and breast cancer, mitochondria and liver regeneration, ovarian cancer and extracellular vesicles.
Biomedicine – hematology & immunology: regulation of production of immune cells, immune memory, molecular tricks of bacterial pathogens to manipulate the host, central and peripheral immune tolerance, autoimmunity.
Workshops: career paths in science-research and alternatives, life with science, scientific communication, research ethics and scientific misconduct.
At the end of the course participants receive the credit.
For more information and online registration, please visit – https://pokroky.img.cas.cz/.
Deadline: 24 October 2024