Open Postdoc Position in Laboratory of Cancer Cell Biology

Project description

Genome instability is one of the hallmarks of cancer. Cell cycle arrest and DNA repair safeguard the integrity of the genome and prevent tumorigenesis. In Laboratory of Cancer Cell Biology, we use molecular/cell biology techniques and animal models to investigate how inherited and acquired defects in the cell cycle checkpoints contribute to tumor development. In particular, we focus on the function of PPM1D and CHK2 that are important regulators of the tumor suppressor p53. The project aims to identify new mechanisms leading to cell transformation and to reveal new vulnerabilities of cancer cells.

Requirements

• Completed PhD in molecular/cell biology/biochemistry or cancer biology
• Deep interest in molecular principles of cellular function
• Good communication skills in English
• Capable of working in a team, but also able to lead own project
• Experience with CRISPR screens, proteomics, 3D tissue culture or mouse work is considered advantage

We offer

• Postdoc position is available for 2 years with possible extension. Starting date is flexible
• Position in a young international team with passion in our work and  leaving space for your ideas
• State-of-art equipment in core facilities of IMG in Prague
• Employee benefits (meal allowance and kindergarten, 5-week vacation)
• No teaching duties

How to apply

Please email your CV and references to macurek@img.cas.cz.

References

1. Storchova et al., Phosphorylation of TRF2 promotes its interaction with TIN2 and regulates DNA damage response at telomeres. Nucleic Acids Research 2023, 51:1154-1172. [pubmed] [doi]
2. Martinikova et al., PPM1D activity promotes the replication stress caused by cyclin E1 overexpression. Molecular Oncology. 2024; 18:6-20. [pubmed] [doi]
3. Burocziova et al. Ppm1d truncating mutations promote the development of genotoxic stress-induced AML. Leukemia. 2023; 37:2209-2220. [pubmed] [doi]
4. Stolarova et al., ENIGMA CHEK2gether Project: A Comprehensive Study Identifies Functionally Impaired CHEK2 Germline Missense Variants Associated with Increased Breast Cancer Risk. Clinical Cancer Research. 2023; 29:3037-3050. [pubmed] [doi]
5. Jaiswal et al., ATM/Wip1 activities at chromatin control Plk1 re-activation to determine G2 checkpoint duration. EMBO J. 2017; 36:2161-2176. [pubmed] [doi]
6. Kleiblova et al. Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint. J Cell Biol. 2013; 201:511-21. [pubmed] [doi]